Comparative study of landiolol and esmolol on antiarrhythmic and safety

VernacularTitle:兰地洛尔和艾司洛尔抗实验性心律失常作用和安全性评价的比较研究
Author: Mei LI ¹ ; Zheng SUN ; Ru-Lin ZHUANG ; Teng-Fei MA ; Shu-Ling GU ; Xing MA ; Ti-Jun DAI
Author Information

1. 徐州医学院药学院药理学教研室
Keywords: landiolol; esmolol; anti-arrhythmia; safety
From: The Chinese Journal of Clinical Pharmacology 2015;(8):640-644
CountryChina
Language:Chinese
Abstract: Objective To compare the antiarrhythmic effects and safety of landiolol and esmolol .Methods The sequential method was used to detect the median lethal dose ( LD50 ) and 50%effective dose ( ED50 ) of the two drugs.Treatment index were calculated by LD 50/ED50 .Several of arrhythmia models were used to study the antiarrhythmic effects of landio-lol and esmolol in the equivalent dose .Results ED50 and LD50 of landio-lol and esmolol were 14.4 , 17.3 mg? kg -1 and 347 , 100 mg? kg -1 re-spectively , TI were 24.1 and 5.8.The ratio of equivalent dose between landiolol and esmolol on anti -chloroform induced arrhythmia was 0.83∶1.Landiolol and esmolol have similar anti -arrythmia effect on va-rious arrhythmia models.Esmolol has a stronger inhibition function on the heart rate than that of landiolol .Conclusion Compared with esmolol , landiolol has similar antiarrhythmic effect , gentle and slow effect on heart rate, higher treatment index and safety in equivalent dose .