Effect of atorvastatin on decreasing a hypertensive response to exercise and improving exercise tolerance
10.13699/j.cnki.1001-6821.2015.08.005
- VernacularTitle:阿托伐他汀钙降低运动高血压反应和改善运动耐量的临床研究
- Author:
Ping-Zhen YE
1
;
Ping-Xian YE
;
Jian-Hua ZHU
;
Dan-Chen GAO
Author Information
1. 金华广福医院 心内科
- Keywords:
atorvastatin;
diastolic dysfunction;
left ventricular;
exercise hypertension;
exercise tolerance
- From:
The Chinese Journal of Clinical Pharmacology
2015;(8):599-602,611
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effect of atorvastatin on exercise blood pressure and exercise tolerance of patients with diastolic dysfunc-tion and hypertensive responses to exercise .Methods Sixty patients with diastolic dysfunction and hypertensive responses to exercise were se-lected and divided randomly into atorvastatin treatment group ( n =30 , atorvastatin 20 mg qn ) and control group ( n =30 ) .All patients con-tinued their original therapy .The course of treatment was one year .The data of cardiopulmonary exercise testing , exercise blood pressure meas-urement , quality of life assessment using heart failure questionnaire were compared before and after treatment . Results After treatment , the resting systolic blood pressure , pulse pressure , and the peak exercise systolic blood pressure were significantly decreased , and exercise time , metabolic equivalent ( METs ) , maximal oxygen uptake ( VO2 max ) and anaerobic threshold ( AT ) were increased , and and quality of life were improved compared with before treatment ( P <0.05 ) . There was statistical difference in the resting systolic blood pressure , the peak exercise systolic blood pressure , and the exercise time between two groups found ( P<0.05 ). Conclusion For patients with diastolic dysfunction and a hypertensive response to exercise , atorvastatin can effectively reduce the blood pressure and peak exercise systolic blood pressure , increase exercise tolerance and improve quality of life .
