Clinical study of clopidogrel combined with aspirin in the treatment of acute myocardial infarction
10.13699/j.cnki.1001-6821.2015.08.004
- VernacularTitle:氯吡格雷联合阿司匹林治疗急性心肌梗死的临床研究
- Author:
Ya-Nan ZHAO
1
;
Chen WANG
;
You-Quan WEI
;
Xiang-Hong LI
;
Heng CAO
Author Information
1. 皖南医学院 弋矶山医院 临床药学部
- Keywords:
acute myocardial infarction;
platelet maximum aggregation rate;
arachidonic acid;
adenosine diphosphate;
collagen
- From:
The Chinese Journal of Clinical Pharmacology
2015;(8):595-598
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the significance of platelet function monitoring in anti -platelet treatment of acute myocardial infarction . Methods The platelet maximum aggregation rates ( MAR ) induced by arachidonic acid , adenosine diphosphate and collagen were detected in 60 cases of acute myocardial infarction .The platelet aggregation function was compared before and after anti -platelet therapy for 24 h and 1 week.The plasma concentration of clopidogrel acid was detected and the correlation between concentration of clopidogrel acid and platelet aggrega-tion was analyzed.Results The MAR induced by arachidonic acid , adenosine diphosphate and collagen were significantly decreased after an-tiplatelet treatment for 24 h( P<0.01 );but after 1 week, no further re-duce in platelet aggregation rate was found , which showed some tole-rance.After 24 h, patients with MAR decreased by more than 30% ac-counted for 36.5%, 40.4% and 21.2%, respectively induced by arachidonic acid , adenosine diphosphate and collagen; patients with MAR decreased by 10% -29% accounted for 30.8%, 25%, and 34.6%,respectively,andthosewithMARdecreasedlessthan10%accountedfor34.6%,36.5%and44.2%,re-spectively.During half year follow -up, 34% of patients showed reoccurrence of cardiovascular events , and 55% of them were found aggregation rate less than 30%.Conclusion The aggregation rates under induction of arachidonic acid, adenosine diphosphate and collagen are all less than 30%when adopting the same anti -palate regime, but the incidence of cardiovascular events increased significantly and the platelet aggregation function and blood concentration of clopidogrel acid has no correlation .
