Clinical effect and safety of minocycline combined with tinidazole on chronic periodontitis
10.13699/j.cnki.1001-6821.2015.08.002
- VernacularTitle:盐酸米诺环素软膏联合替硝唑治疗慢性牙周炎的临床疗效及安全性研究
- Author:
Da-Feng ZHANG
1
;
Sheng-Bin HUANG
;
You-Ting ZHANG
;
Hui DENG
Author Information
1. 温州医科大学 附属口腔医院
- Keywords:
chronic periodontitis;
minocycline;
tinidazole;
clinical effi-cacy;
safety
- From:
The Chinese Journal of Clinical Pharmacology
2015;(8):590-591,594
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the clinical effect and safety of mino-cycline combined with tinidazole on chronic periodontitis .Methods A total of 102 patients with chronic periodontitis were recruited in this pro-spective study and were divided into experiment group ( n=49 ) and con-trol group ( n =53 ) .Patients in control group were given minocycline once a week for 4 weeks and patients in experiment group were given mi-nocycline once a week plus tinidazole 250 mg per day for 4 weeks.The data of clinical efficacy and adverse reactions were evaluated after the treatment.Results The excellence rate were 93.8%and 63.3%in ex-periment and control group respectively , which indicated a higher rate in experiment group but with out statistical difference (P>0.05).And the adverse reactions such as nausea , itchy skin and dizziness were not statis-tically different between the two groups ( P<0.05 ).Conclusion Mino-cycline combined with tinidazole in the treatment of chronic periodontitis is effective , and not increasing the adverse reactions .
