Experimental study on pharmacodynamics and acute toxicity of compound Jinshalidan Granules
10.13699/j.cnki.1001-6821.2015.07.022
- VernacularTitle:复方金沙利胆颗粒药效学及急性毒性研究
- Author:
Ai-Ling YI
1
;
Fu-Sheng ZOU
;
Ying-Ying WEI
;
Wei CHEN
;
Guang DU
Author Information
1. 武汉市黄陂区人民医院 药剂科
- Keywords:
Compound Jinshalidan Granule;
pharmacodynamics;
cholagogic;
anti-inflammatory;
acute toxicity
- From:
The Chinese Journal of Clinical Pharmacology
2015;(7):560-562,572
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the cholagogic and anti -infla-mmatory effects and acute toxicity of Jinshalidan Granules.Methods The cholagogic effect of Jinshalidan Granules was observed and deter-mined by common bile duct drainage in mouse .The acute inflammatory models was established by xylene -induced ear edema to research the inflammatory effects of Jinshalidan Granules.The acute toxicity and the maximum tolerated dose in mice were also studied.Results Compared with the normal control group , the bile secretion for the mouse and the degree of swelling of mice ear induced by xylene were significantly improvemed in all the 3 different dosages of Jinshalidan Granules.After 14 days, continuous observation ,no mouse was found dead and no signifi-cant toxicity occurred by naked eyes.The maximum tolerated dose of Compound Jinshalidan Granules is 244.8 g · kg -1 ( crude drug ).Conclusion Compound Jinshalidan Granules have obviously effects on the increased the bile secretion and anti -inflammatory ,it is has very low acute toxicity in mice and preliminary proven to be safe .
