Effects of diazepam on the percentage of δ -band power of quantitative pharmaco-electroencephalogram in rabbits
10.13699/j.cnki.1001-6821.2015.07.016
- VernacularTitle:地西泮与氟马西尼合用对兔定量药物脑电图δ频段功率百分比的影响
- Author:
Qing WANG
1
;
Jian ZHAO
;
Ling-Ling LI
;
Ti-Jun DAI
Author Information
1. 徐州医学院研究生学院
- Keywords:
diazepam;
flumazenil;
quantitative pharmaco -electroencephalogram;
degree of sedation and hypnosis;
δ-band
- From:
The Chinese Journal of Clinical Pharmacology
2015;(7):540-543
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effects of diazepam on the percen-tage of δ -band power of quantitative pharmaco -electroencephalogram ( QPEEG ) in rabbits and the relation with benzodiazepine receptor.Methods Thirty-six healthy rabbits were randomly divided into 6 groups (each n=6),where rabbits in each group were intravenously injected with 1 mL· kg-1 0.9%NaCl (blank group), 0.12 mg· kg-1 , 0.25 mg· kg-1 or 0.50 mg· kg-1 diazepam groups, 0.1 mg· kg-1 flumazenil group and 0.1 mg· kg-1 flumazenil +0.5 mg· kg-1 diazepam ( combined group ).Then a digital EEG system was adopted to record the changes of QPEEG in eight encepha-lic regions before and after injection at each time point.Results The per-centage of δband power in eight encephalic regions of 0.25, 0.50 mg· kg-1 diazepam groups are noted increase within 0.5 to 30 min.The change of the percentage of δ band power has a positive correlation with diazepam dose.Compared with the 0.5 mg· kg-1 diazepam group,the percentage of δ-band power in combined group was lower at same time point.Conclusion Diazepam increases the percentage ofδ-band power of QPEEG in the way of dose dependence in rabbits.It indicates that benzodiazepine receptor mediates the effect of diazepam and the percentage of δ-band power may become an index that reflects the degree of sedation and hypnosis.
