Cardioprotective effects of liraglutidein rat myocardial ischemia -reperfusion injury studies
10.13699/j.cnki.1001-6821.2015.07.006
- VernacularTitle:利拉鲁肽对大鼠心肌缺血再灌注损伤的保护作用
- Author:
Xiao-Huan TENG
1
;
Xiong WANG
;
Xiang-Juan CHENG
Author Information
1. 山西医科大学 第一临床医学院
- Keywords:
liraglutide;
ischemia -reperfusion injury;
myocardial infarction size;
apoptosis
- From:
The Chinese Journal of Clinical Pharmacology
2015;(7):505-507
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect and the mechanism of li-raglutideon myocardial ischemia reperfusion injury in rat.Methods Healthy male SD rats were randomly divided into three groups: shame-operated group , ischemia reperfusion ( I/R ) group, liraglutidegroup ( 70μg· kg -1 ) , 8 rats in each group.The rat model of myocardial I/R was established by occlusion of the left anterior descending coronary artery for 30 minutes and reperfusion for 120 minutes.The area at risk was deter-mined using Evans blue and infarct area using triphenyl tetrazolium chlo-ride staining.Apoptosis of myocardial cells was detected with in situ end labeling , and expressions of myocardial apoptosis proteins Bcl -2 and Bax were detected with immunohist ochemical method.Results In com-parison with ischemia reperfusion group , the myocardial infarction size and the number of apoptotic cells were reduced ( P<0.05 ) , the expre-ssion of Bcl-2 protein was increased and Bax protein was decreased in liraglutide group ( P<0.05 ).Conclusion liraglutidecan protects cardio-myocytes from ischemia reperfusion injury by inhibiting cell apoptosis.
