Escitalopram oxalate combined with olanzapine in the treatment of depressive disorder in elderly patients
10.13699/j.cnki.1001-6821.2015.07.003
- VernacularTitle:草酸艾司西酞普兰联合奥氮平治疗老年抑郁症的临床疗效及安全性研究
- Author:
Xue-Bao ZHENG
1
;
Hong-Fei WANG
;
Xin-Jun WU
;
Wei-Fang ZHENG
Author Information
1. 黄岩区第三人民医院 精神科
- Keywords:
olanzapine;
escitalopram oxalate;
elderly;
depressive disorder;
clinical efficacy
- From:
The Chinese Journal of Clinical Pharmacology
2015;(7):495-497
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess the clinical efficacy and adverse reac-tions of olanzapine combined with escitalopram oxalate on depressive disorder in elderly patients.Methods Sixty two elderly patients with depressive disorder were recruited from February 2012 to April 2014 in our hospital and were randomized divided into the control group ( n=33 ) and experiment group ( n=29 ).Patients in the control group were given escitalopram oxalate 10 mg · d-1 orally for 8 weeks and patients in the experiment group were given escitalopram oxalate 10 mg · d-1 combined olanzapine 2.5 mg· d-1 ( initially) ,ranging from 5 to 10 mg· d-1 within the first week.The data of hamilton depression scale ( HAMD) and treat-ment emergent symptom scale ( TESS ) score were recorded between the two groups to evaluate the clinical efficacy and adverse reactions before treatment and 1, 2, 4, 6 and 8 weeks after treatment.Results From the end of the second week to the eighth week , the HAMD scale were significantly decreased in both groups ( P <0.05 ).At the end of the fourth week to the eighth week , the HAMD score in the experiment group were significantly lower than those in control group ( P <0.05 ).After 8 weeks, more than 10%patients in the experiment group showed weight gain , higher than those in the control group (P<0.05).The other adverse reactions such as dizziness , dry mouth, constipation and nausea showed no statistical differences( P>0.05 ).Conclusion Olanzapine combined with escitalopram oxalate in the treatment of depressive disorder in elderly patients can rapidly improve the symptom and have better clinical efficacy , but the weight gain was a common adverse reaction.
