Clinical effect of sitagliptin on type 2 diabetes and its influence on serum glucose transporter-4
10.13699/j.cnki.1001-6821.2015.07.002
- VernacularTitle:西格列汀治疗2型糖尿病的临床疗效及其对血清葡萄糖转运蛋白4的影响
- Author:
Zong-Ai ZHOU
1
;
Nian-You CHEN
;
Zhi-Yue TANG
;
Wei FANG
;
Jin-Bo YIN
Author Information
1. 苍南县人民医院 内分泌科
- Keywords:
type 2 diabetes mellitus;
sitagliptin;
acarbos;
glucose transporter-4
- From:
The Chinese Journal of Clinical Pharmacology
2015;(7):491-494
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical effect of sitagliptin therapy in patients with type 2 diabetes and its effect on glucose trans-porter-4 ( GLUT4).Methods Sixty four patients with type 2 diabetes were randomly divided into two groups , and patients in the observation group (n=32) were given sitagliptin 100 mg qd orally, and those in the control group ( n=32 ) were given acarbose 50 mg tid within meals.The treatment lasted for 12 weeks.The data of the clinical efficacy of the two groups were compared before and after treatment.While 30 healthy controls were selected , only given health education.Data of the expre-ssion of GLUT4 in serum of three groups were detected.Results In ob-servation group , the data of fasting blood glucose ( FBG) , 2 h postprandi-al blood glucose(2 h PG)and glycosylated hemoglobin(HbA1c) were ob-viously better than those in the control group [(6.32 ±0.44 ),(8.76 ± 0.93),(6.85 ±0.37)mmol· L-1 vs(6.44 ±0.46),(9.15 ±0.94), (6.98 ±0.28)mmol· L-1],(P<0.05).The islet beta cell function index in observation group was improved significantly compared with the control group [(2.59 ±0.22),(66 ±18) vs(2.78 ±0.39),(62 ±13)], (P<0.05).The data of serum levels of GLUT4 in the observation group was significantly higher than that in control group [(6.07 ±0.59)vs(2.58 ±0.45)μg· L-1](P <0.05).Conclusion Sitagliptin can effectively control the level of blood sugar , improve islet beta cell function , and the effect may be related to the up -regulation of GLUT4 ex-pression.
