Effect of statin on improves cardiac diastolic function and reduces exercise B-type natriuretic peptide level
10.13699/j.cnki.1001-6821.2015.07.001
- VernacularTitle:他汀类药物治疗改善患者心脏舒张功能与降低运动后脑利钠肽水平的作用
- Author:
Ping-Zhen YE
1
;
Ping-Xian YE
;
Jian-Hua ZHU
;
Dan-Chen GAO
Author Information
1. 金华广福医院 心内科
- Keywords:
statins;
cardiac diastolic function;
B -natriuretic peptide;
hypertension
- From:
The Chinese Journal of Clinical Pharmacology
2015;(7):487-490,504
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effects of statin on cardiac dias-tolic function and the level of B -type natriuretic peptide ( BNP) to exer-cise.Methods A total of 60 patients with diastolic dysfunction and a hypertensive response to exercise were divided into atorvastatin treatment group( n =30, atorvastatin 20 mg, once every night ) and the placebo group(n=30).The course of treatment was one year , all patients con-tinued their original therapy.Echocardiography , cardiopulmonary exer-cise testing , and the plasma BNP concentration determination at peak exercise were performed before and after treatment.Results After ator-vastatin treatment , the mitral flow velocity E wave to A wave peak veloci-ties( E/A ratio) were improved.The exercise time extended , metabolic equivalents , maximal oxygen uptake and anaerobic threshold were increased , and the exercise BNP values reduced.All of parameters had significant difference from baseline (P<0.05), only the E/A ratio,the exercise time and the exercise BNP values had significant difference com-pared with placebo ( P<0.05 ).Conclusion Atorvastatin improves car-diac diastolic function , decreases exercise BNP level , increases exercise tolerance.
