System review on influence of genetic polymorphisms of cytochrome P450 2A6 and 2B6 on blood concentration of valproic acid

VernacularTitle:细胞色素 P4502 A6与2 B6基因多态性影响丙戊酸血药浓度的系统评价
Author: Jie DENG ¹ ; Dao-Hua SHI ; Ya-Yun SHI
Author Information

1. 福建省妇幼保健院药剂科
Keywords: cytochrome P450 2 A6; cytochrome P450 2 B6; gene polymorphism; sodium valproate; blood concentration
From: The Chinese Journal of Clinical Pharmacology 2015;(5):392-394
CountryChina
Language:Chinese
Abstract: Objective To evaluate the influence of the polymorphisms of cytochrome P450 2A6 and 2B6 (CYP2A6, CYP2B6) in plasma concen-tration /dose ratio ( C/D) of valproic acid.Methods DataBases inclu-ding PubMed, EMbase, China national knowledge internet, Weipu and Wanfang were searched for the study on the relationship of the polymor-phisms of CYP2A6 and CYP2B6 in C/D of valproic acid.Meta analysis was performed by RevMan 5.1.Results Five researches were collect-ed, in which the results showed that the C/D in CYP2A6*1/*1 carri-ers was higher than that in*1/*4 +*4/*4 carriers ( P<0.05 ) as well the C/D in CYP2 B6*1/*1 carriers was higher than that in*1/*6+*6/*6 carriers ( P<0.05 ).Conclusion The polymorphisms of CYP2A6*4 and CYP2B6*6 have clinical value in the prediction of blood concentration of valproic acid.