Effects of risperidone on lipid and thyroid hormones in schizophrenic patients

VernacularTitle:利培酮对精神分裂症患者血脂和甲状腺激素的影响
Author: Ming-Kun ZHAO ¹ ; Ye-Hong LIU ; Ping ZHANG ; Yan-Chao HAN ; Ai-Hua WAN ; Xue-Li ZHOU
Author Information

1. 河北省精神卫生中心精神科
Keywords: risperidone; schizophrenia; thyroxine; blood lipid
From: The Chinese Journal of Clinical Pharmacology 2015;(5):342-344
CountryChina
Language:Chinese
Abstract: Objective To observe the effects of risperidone on lipids and thyroid hormone in patients with schizophrenia.Methods Forty-one cases of schizophrenia patients were enrolled from May to October in 2011 , respectively and were treated with risperidone alone for 8 weeks.The data of the total cholesterol (TC), triglyceride (TG), low density cholesterol ( LDL-C ) , and high density cholesterol ( HDL -C ) were measured before and after treatment.The data of three serum triiodothy-ronine (T3), thyroxine three (T4), free triiodothyronine (FT3), free thyroxine ( FT4) and thyroid stimulating hormone ( TSH) were detected.The changes were recorded and compared.Results After risperidone therapy, TG increased significantly compared with before treatment ( P<0.01).The data of T3, FT3 and FT4 decreased significantly ( P<0.01) .Conclusion Risperidone may cause abnormal drop of blood lipid and thyroid hormone level, therefore, related monitors should be strengthened to ensure the safety during treatment of schizophrenia patients.