Effect and safety of escitalopram combined with zolpidem in treatment of primary insomnia patients
10.13699/j.cnki.1001-6821.2015.05.006
- VernacularTitle:艾司西酞普兰联合唑吡坦治疗原发性失眠的临床疗效和安全性评价
- Author:
Hong-Jing MAO
1
;
Lian-Lian XU
;
Yi LIU
Author Information
1. 杭州市第七人民医院 医学心理科
- Keywords:
escitalopram;
zolpidem;
primary insomnia;
efficacy;
safety
- From:
The Chinese Journal of Clinical Pharmacology
2015;(5):339-341
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the efficacy and safety of escitalo-pram combined with zolpidem and zolpidem alone on primary insomnia.Methods A total of 72 primary insomnia patients were recruited from outpatients in the Seventh Hospital of Hangzhou and were randomly divided into test group (n=36)and control group (n=36).Patients in the test group were treated with escitalopram 10-20 mg· d-1 combined zolpidem 5 -10 mg · d -1 for 8 weeks, while patients in control group were treated with zolpidem 5 -10 mg · d-1 only.The efficacy and ad-verse events were assessed with the pittsburgh sleep quality index (PSQI), patient health questionnaire(PHQ-9)and treatment emergent symptom scale ( TESS ) before and after 1, 4 and 8 weeks treatment.Results The score of PSQI and PHQ-9 in two groups were decreased significantly at week 1, 4, 8 after treatment(P<0.05).The scores of PSQI and PHQ-9 was lower in test group than that in control group at the end of 8 weeks after treatment( P<0.05).There were similar rates of adverse reactions between two groups ( P >0.05 ).Conclusion Escitalopram combined with zolpidem is significantly effective and safe for primary insomnia patients.
