Evaluation of trazodone for treatment of sleep disorders and anxiety in methamphetamine addicts after detoxification
10.13699/j.cnki.1001-6821.2015.05.005
- VernacularTitle:曲唑酮对甲基苯丙胺依赖者脱毒后睡眠障碍和焦虑情绪的临床疗效观察
- Author:
Yue LIU
1
;
Yan-Yan HUANG
;
Wen-Wen SHEN
;
Jian-Bing ZHANG
;
Wen-Hua ZHOU
Author Information
1. 宁波市微循环与莨菪类药研究所
- Keywords:
methamphetamine addict;
anxiey;
sleep quality;
pittsburgh sleep quality index;
trazodone
- From:
The Chinese Journal of Clinical Pharmacology
2015;(5):336-338
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of trazodone on sleep disorders and anxiety in methamphetamine addicts after detoxification. Methods One hundred and six cases were randomly divided into control group(n=53)and treatment group(n=53).Patients in treatment group were given trazodone, while the controls were given placebo, when the detection of methamphetamine in urine were all negative.All of them were toxicity-free and were accessed by pittsburgh sleep quality index ( PSQI) and hamilton anxiety scale ( HAMA) before treatment and at the end of the first week, the second week and the fourth week.The effect of trazodone on sleep quality and anxiety in methamphetamine addicts were observed.The treatment emergent symptom scale ( TESS ) was used to make safety evaluation.Results Compared with the control group, the data PSQI and HAMA decreased significantly in the treatment group at the end of the second week and the fourth week (P<0.05).Conclusion Trazodone is effective in improving sleep disorders and reducinganxiety of methamphetamine addict after detoxification.It cansignificantly prevent relapse.
