Advance of progesterone and the signal pathway of phosphatidylinositol 3-kinase/protein kinase B in hypoxic ischemic brian damage
10.13699/j.cnki.1001-6821.2015.04.025
- VernacularTitle:孕酮和 PI3 K/Akt信号通路在缺氧缺血性脑损伤中的研究现状
- Author:
Zhi-Liang XU
1
;
Wei-Ping CHEN
;
Sen ZHONG
Author Information
1. 武汉大学人民医院儿科
- Keywords:
neonate;
hypoxic ischemic encephalopathy;
progesterone;
phosphoinositide 3-kinase/protein kinase B
- From:
The Chinese Journal of Clinical Pharmacology
2015;(4):317-320
- CountryChina
- Language:Chinese
-
Abstract:
Phosphatidylinositol 3 -kinase /protein kinase B ( PI3 K/Akt) is a classic anti -apoptotic and pro -survival signaling pathway, which plays a role in the regulation of cerebral infarction, Parkinson's dis-ease , epilepsy and other neurological diseases.Progesterone is one of the fat-soluble sex hormones, which has been proved to have neuro-pro-tective effect on nerological disease, such as brain injury, stroke and Alzheimer's disease, and it′s relevant to the up-regulation of p-Akt. Studies about the advance of neonatal hypoxic ischemic encephalopathy ( HIE) , progesterone and PI3K/Akt were collected and reviewed, antici-pating that it will provide theoretical basis for the further research of the relationship between progesterone and the signal pathway of PI3K/Akt in HIE.
