Advance of platelet activating factor in drug-induced anaphylaxis
10.13699/j.cnki.1001-6821.2015.04.022
- VernacularTitle:血小板活化因子在药源性严重过敏反应中的研究现状
- Author:
Xiang MA
1
;
Xiao-Xiao LI
;
Wei LIU
;
Suo-Di ZHAI
Author Information
1. 北京大学第三医院药剂科
- Keywords:
drug-induced anaphylaxis;
platelet activating factor;
platelet activating factor acetylhydrolase
- From:
The Chinese Journal of Clinical Pharmacology
2015;(4):308-311
- CountryChina
- Language:Chinese
-
Abstract:
The acute unpredictably life -threatening characteristic of drug-induced anaphylaxis hinders the safe use of clinical medication.In the absence of rigid randomized controlled trials supporting the recommen-dations for the treatment of immediate onset, doctors often treat drug-induced anaphylaxis with epinephrine, antihistamines and/or glucocorticoids.The researches in platelet activating factor signaling path-way could provide a novel perspective for drug-induced anaphylaxis.This review will briefly introduce the clinical and epidemiological characteristics of drug-induced anaphylaxis, platelet activating factor pathway and drugs targeting at this pathway.
