Naloxone′s inhibition on the effects of sulfentanil on percentage ofβ1-band power of quantitative pharmaco-electroencephalography in rabbits
10.13699/j.cnki.1001-6821.2015.04.015
- VernacularTitle:纳洛酮拮抗舒芬太尼的兔定量药物脑电图β1频段功率百分比效应
- Author:
Dan ZHANG
1
;
He LI
;
Xiao-Qing WANG
;
Jia-Wen XU
;
Ya-Mei YU
;
Ti-Jun DAI
Author Information
1. 徐州医学院研究生院
- Keywords:
sulfentanil;
naloxone;
opioid receptor;
analgesia degree;
quantitativepharmaco-electroencephalogram;
β1 -band
- From:
The Chinese Journal of Clinical Pharmacology
2015;(4):286-288,291
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effects of sulfentanil on the per-centage of β1 -band power of quantitative pharmaco-electroencephalo-graphy ( QPEEG ) in rabbits, and its relationship with opioid recep-tor.Methods Thirty-six healthy rabbits were divided randomly into six groups(n=6):normal group (0.9%NaCl 1 mL? kg-1), low, medium, high doses sulfentanil groups ( 1.5 , 3 , 6 μg? kg -1 ) , naloxone group (400 μg? kg-1 ) and naloxone and sulfentanil group ( naloxone 400μg? kg -1 and sulfentanil 3 μg? kg-1 ) .The percentage of each band power was respectively noted down 30 s before administration and 1, 3, 5, 10, 20, 25 min after administration.Results Compared with the baseline, the percentage ofβ1 -band power was decreased in the groups of medium, high doses sulfentanil ( P <0.05 ) , which had a negative correlation with sulfentanil dose ( P <0.05 ) . There was no obvious change in the percentage of β1 -band power in the group of naloxone compared with the baseline ( P >0.05 ) .Conclusion Sulfentanil de-creases the percentage ofβ1 -band power in a dose-dependent manner, and this effect is mediated by the opioid receptor.
