In vitro activity of Yinhua Miyan Ling
10.13699/j.cnki.1001-6821.2015.04.013
- VernacularTitle:银花泌炎灵体外抗菌作用研究
- Author:
Yun LI
1
;
Yuan LV
;
Jian LIU
;
Feng XUE
;
Wei-Wei YANG
;
Jia ZHANG
Author Information
1. 北京大学 第一医院 临床药理研究所
- Keywords:
Yihua Miyan Ling;
in vitro activity;
combination effect
- From:
The Chinese Journal of Clinical Pharmacology
2015;(4):279-282
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluation in vitro activity and synergy of Yin-hua Miyan Ling against main clinical isolated strains.Methods All of 285 stains from 18 tertiary hospitals in recent three years were studied. Minimal inhibition concentrations ( MIC ) were tested by Agar dilution method and combination effects were measured by Checkerboard method. Results Yinhua Miyan Ling showed more in vitro activity against Sta-phylococcus and Proteus mirabilis, MIC values from 3.13~6.25 mg? mL-1 . On the other hand, Yinhua Miyan Ling showed the same antibiotic activi-ty against extended-spectrumβlactamases ( ESBLs) positive and nega-tive strains or methecillin susceptible and resistant Staphylococcus.Syner-gy was detected with Yinhua Miyan Ling in combination with amoxillin/clavulanate, cefuroxime and levofloxacin against gram-positive strains, especially methicillin-resistant Staphylococcus aureus ( MRSA).Against E.faecalis, synergy was observed in Yinhua Miyan Ling and cefuroxime. Additive effect was found between Yinhua Miyan Ling and amoxillin/clavulanate against 100%E.coli.Conclusion Synergy was found with Yinhua Miyan Ling in combination withβlactams and quinolones against gram -positive strains and additive effect was found against gram-negative bacilli.
