Effect of Shenqifuzheng injection combined with chemotherapy on breast cancer
10.13699/j.cnki.1001-6821.2015.04.009
- VernacularTitle:参芪扶正注射液联合化疗方案对乳腺癌患者的临床疗效
- Author:
Xiao-Lei LI
1
;
Xiao-Qi WANG
;
Hai-Ou QU
Author Information
1. 温岭市第一人民医院 外科
- Keywords:
Shenqifuzheng injection;
mammary cancer;
soluble interleukin 2 receptor;
interleukin 6;
tumor necrosis factor alpha
- From:
The Chinese Journal of Clinical Pharmacology
2015;(4):267-269
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical effect of Shenqifuzheng injection combined with CAF regmien on expression of soluble interleukin 2 receptor(sIL2R), interleukin 6(IL-6), tumor necrosis factor alpha ( TNF-α) in breast cancer patients.Methods One hundred and sixty patients with mammary cancer were randomly divided into the observed group(n=80) and patients in the control group(n=80).They all ac-cepted the treatment of CAF regmien, and patients in the observed group accepted the treatment of Shenqifuzheng injection as well.The concentra-tion of sIL2R, IL -6 and TNF -αwere detected by enzyme -linked immunosorbent assay before and after treatment.Results After treat-ment, the effective rate in the observed group(55.00%) was significant-ly higher than that in the control group(38.75%)(P<0.05);the con-centration of sIL2R, IL-6 and TNF-αafter treatment were significantly lower than those before treatment in the both of the two groups (P<0.01);the concentration of sIL2R, IL-6 and TNF-αin the ob-served group was significantly lower than those in the control group ( P<0.01);the incidence of adverse reactions like blood cells reduce in the observed group ( 35.00%) was significantly lower than that in the control group(52.50%)(P<0.05).Conclusion shenqifuzheng injec-tion could reduce the concentration of sIL2R, IL -6 and TNF -αin breast cancer patients, improve the clinical efficacy, and reduce the adverse reactions.
