Recombinant human interferon α2b vaginal effervescent capsules in the treatment of patients with human papilloma virus infection
10.13699/j.cnki.1001-6821.2015.04.006
- VernacularTitle:重组人干扰素α2b阴道泡腾胶囊治疗宫颈人乳头瘤病毒感染的临床研究
- Author:
Ai-Qin HU
1
;
Jin-Hua WANG
Author Information
1. 浙江省长兴县妇幼保健院 妇产科
- Keywords:
recombinant human interferonα2 b vaginal effervescent capsule;
human papilloma virus;
cervical erosion
- From:
The Chinese Journal of Clinical Pharmacology
2015;(4):259-260,263
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the clinical efficacy of recombinant human interferon α2b vaginal effervescent capsules on patients with hu-man papilloma virus ( HPV ) infection.Methods One hundred and twenty-eight patients with HPV infection were recruited in this prospec-tive study from October 2011 to October 2013 and randomly divided into the treatment group (n=62) and the control group (n=66).Patients in the treatment group were given one human interferon α2 b vaginal effer-vescent capsule per day.The treatment lasted for 3 cycles (10 days as a cycle) .Patients in the control group were followed up and observed. After 3-month treatment, the data of HPV infection rate, cervical ero-sion and side effects in two group were compared.Results After treat-ment, forty -eight cases in the treatment group became HPV negative (77.4%) and 4 cases become HPV negative (6.1%) in control group, which showed the negative rate in the treatment group was much higher than that in the control group ( P<0.05);the effective rates on cervical erosion were 63.8%(30/47) and 8.3%(4/48) respectively in treatment group and control group ( P<0.05 ) .There were no significant adverse reactions found in the treatment group.Conclusion The recombinant human interferon α2 b vaginal effervescent capsule for the treatment of HPV infection is significantly effective, relieving the seriousness of cervical erosion as well.
