Pharmacokinetics of oral administration of febuxostat tablet in Chinese healthy volunteers
10.13699/j.cnki.1001-6821.2015.03.013
- VernacularTitle:中国健康受试者口服非布司他片的药代动力学研究
- Author:
Fu-Rong QIU
1
;
Lei-Lei ZHU
;
Jian JIANG
;
Min HE
;
Tong-Fang ZHAO
;
Yu-Jie YE
;
Shu-Jiao SHEN
;
Lin GUO
;
Meng-Meng WANG
Author Information
1. 上海中医药大学附属曙光医院 临床药理科
- Keywords:
febuxostat;
LC-MS/MS;
pharmacokinetic
- From:
The Chinese Journal of Clinical Pharmacology
2015;(3):199-202
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate pharmacokinetics of febuxostat in Chinese healthy volunteers.Methods Twenty -four volunteers were assigned into two groups taking different doses (40, 80 mg) of febuxostat tablets.Subjects received single 40 mg and multiple 40 mg or single 80 mg doses of febuxostat tablets.Plasma samples were collected over 24 h and the plasma concentrations were determined by LC-MS/MS.Results After 40 mg and 80 mg single dose administration of febuxostat, Cmax were (1873.55 ±735.94) and (3899.17 ±1577.54) ng· mL-1, tmax were (1.86 ±1.10) and (2.15 ±1.75) h, t1/2 were (5.57 ±1.32) and (4.87 ±0.86) h, CL/F were (6.44 ±1.97) and (6.15 ±2.15) h· L-1, and AUC0-24 h were (6651.10 ±2319.72) and (1.43 ×104 ±5033.26) ng· h · mL-1 , respectively.Following febuxostat tablet at 40 mg dose daily for 5 consecutive days, the pharmacokinetic parameters in steady state were similar to those taking a single dose of this drug.Conclusion There was no significant difference in pharmacokinetics parameters of febuxostat adjusted by weight as compared with other races.So, clinical usage of febuxostat can refer to the foreign clinical regime.
