Influence of preoperative chemotherapy of S -1 or capecitabine on CK20mRNA expression in peripheral serum in patients with colorectal cancer
10.13699/j.cnki.1001-6821.2015.03.009
- VernacularTitle:替吉奥与卡培他滨术前新辅助化疗对结直肠癌外周血细胞角蛋20核糖核酸表达的影响
- Author:
Lin FU
1
;
Kai QIN
Author Information
1. 资阳市第二人民医院 普外科
- Keywords:
S-1;
capecitabine;
colorectal cancer;
CK20 mRNA
- From:
The Chinese Journal of Clinical Pharmacology
2015;(3):187-189
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the influence of preoperative chemotherapy of S-1 or capecitabine on the serum CK20mRNA expres-sion in peripheral serum in patients with colorectal cancer.Methods Eighty -seven patients undergoing colorectal cancer radical operation from Feb 2010 to Aug 2013 were retrospectively analyzed.Of the 87 subjects, 31 subjects were given S-1 orally ( S-1 group) , 26 subjects given capecitabine ( capecitabine group ) orally and 30 not given any of them (control group).The data of CK20mRNA level of peripheral blood and positive rates of the three groups were tested and compared.Results The serum CK20mRNA positive rate in the S -1, capecitabine and control group were 51.6%( 16/31 ) , 46.2%( 12/26 ) and 83.3%(25/30), which suggested that the positive rate in control group was much higher than those in S-1 and capecitabine group ( P<0.05 ) , and there was no statistical difference found between S-1 group and capecita-bine group.The average serum CK20 mRNA expression level were (0.15 ±0.11), (0.14 ±0.09) and (0.89 ±0.46), respectively, which indicated that the data of control group was much higher than those in other two groups ( P<0.05 ) , and there was no statistical difference found between S -1 group and capecitabine group ( P >0.05 ). Conclusion Preoperative administration of S-1 and capecitabine in patients with colorectal cancer can significantly decrease the relative copy number and positive rate of CK20mRNA.
