Progress in the early warning and prevention of valproate-induced hepatotoxicity
10.13699/j.cnki.1001-6821.2015.02.022
- VernacularTitle:丙戊酸肝毒性的早期预警及预防研究状况
- Author:
Can WANG
1
;
Hong-Ying MA
;
Fang-Jie WANG
;
Ai-Ying KONG
Author Information
1. 中南大学湘雅医院药学部
- Keywords:
valproate acid;
hepatotoxicity;
2 -propyl -4 -pentenoic acid
- From:
The Chinese Journal of Clinical Pharmacology
2015;(2):150-154
- CountryChina
- Language:Chinese
-
Abstract:
Valproate acid is widely used not only as the first -line antie-pileptic drugs but also in the treatment of other neurological diseases.Hepatotoxicity is a serious adverse reaction of valproate acid.The children younger than 2 years of age undergoing polytherapy appear to be at a significantly increased risk for severe hepatotoxicity even fatal hepa-totoxicity.Therefore , choosing a more suitable biomarker to warn the occurrence of valproate-induced hepatotoxicity is as important as early prevention through drug intervention.The aim of this article was to re-view the early warning and prevention of this complication in recent years.
