Review on pharmacokinetic/pharmacodynamic models of the related agents of incretin
10.13699/j.cnki.1001-6821.2015.02.021
- VernacularTitle:肠促胰岛素相关药物的药代动力学／药效学模型研究进展
- Author:
Yan-Nan ZANG
1
;
Yi FANG
Author Information
1. 北京大学人民医院药剂科
- Keywords:
incretin;
glucagon -like peptide -1 receptor agonists;
dipeptidyl peptidase -4 inhibitors;
pharmacokinetic/pharmacodynamic models
- From:
The Chinese Journal of Clinical Pharmacology
2015;(2):146-149
- CountryChina
- Language:Chinese
-
Abstract:
Incretin is a hormone released from the L -cells in the gut wall under the stimulation of food and can promote the insulin secretion.The related agents used in the clinic mainly include two types , the gluca-gon-like peptide-1 ( GLP-1 ) receptor agonists and dipeptidyl pepti-dase -4 ( DPP -4 ) inhibitors.Pharmacokinetic/pharmacodynamic ( PK/PD) models of incretin related agents can be useful tools in optimal drug therapy in patients and support the design of future clinical trials.Meanwhile , a mechanism-based model can be more powerful at predic-ting physiological characteritics and the probability of successful outcome of anti -diabetic treatment for different dosage regimens of the drugs , which will be beneficial for new drugs development and dosage regimens regulation.The present review is focused on the mechanism -based PK/PD models of representative drugs which belong to GLP -1 receptor agonists and DPP-4 inhibitors.
