Methyl testosterone combined with mifepristone in the treatment of perimenopausal dysfunctional uterine bleeding
10.13699/j.cnki.1001-6821.2015.02.016
- VernacularTitle:甲基睾丸素联合米非司酮治疗围绝经期功能性子宫出血的疗效评价
- Author:
Jian-Hua LI
1
;
Ji-Fen HU
Author Information
1. 福建医科大学 附属第一医院 妇产科
- Keywords:
methyl testosterone;
mifepristone;
functional uterine blee-ding;
hormone
- From:
The Chinese Journal of Clinical Pharmacology
2015;(2):132-134
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the clinical efficacy of methyl testos-terone combined with mifepristone on hormone and perimenopausal func-tional uterine bleeding ( FUB).Methods Fifty-six patients with FUB received methyl testosterone 5 mg qd for 90 days and mifepristone 25 mg qd for 105 days.The endometrial thickness and hormonal were measured before and after the treatment.The data of menstruation were recorded in two-year follow -up.Results The endometrial thickness was signifi-cantly decreased after the treatment ( P <0.05 ) and the serum estrogen and progesterone were much lower after treatment than that of before treatment(P<0.05).During the period of treatment , all of the fifty -six patients occurred amenorrhea , 9 case with normal menstruation , 14 cases of menstrual scarce and 33 cases of menopause after treatment.With 2 -year follow -up, eight patients had abdominal pain again , irregular vaginal bleeding and other symptoms , and the recurrence rate was 14.3%.Conclusion Methyl testosterone combined with mifepris-tone in the treatment of FUB can significantly reduce the thickness of the endometrium with satisfactory clinical efficacy and mild adverse reactions .
