Evaluation on the therapeutic drug monitoring data of vancomycin and its efficacy and renel toxicity in elder patients
10.13699/j.cnki.1001-6821.2015.02.014
- VernacularTitle:老年患者万古霉素血药浓度监测与疗效评估
- Author:
Dan QU
1
;
Yu CHEN
;
Xiu GU
;
Xiao-Man XU
Author Information
1. 中国医科大学 附属盛京医院 呼吸科
- Keywords:
elderly;
vancomycin;
serum drug monitoring;
renal toxicity
- From:
The Chinese Journal of Clinical Pharmacology
2015;(2):127-129
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the drug plasma concentration , clini-cal efficacy and renal toxicity of vancomycin .Methods The clinical da-ta ( basic disease , bacteriological results , the serum concentrations of vancomycin , clinical efficacy , renal toxicity and initial dose selection ) of 39 elder patients were retrospectively analyzed.Results The effective rate of vancomycin was 82.05%.Vancomycin trough concentration be-tween 10-20 mg · L-1 accounted for 48.12%.Among the 19 patients whose vancomycin trough concentrations were less than 10 mg · L-1 , 6 cases adjusted the dose , 2 cases ( 5.13%) had renal toxicity , but the creatinine returned to basal levels after vancomycin was reduced or stopped.Renal toxicity didn′t appear in 3 cases (7.69%) who had renal insufficiency before using vancomycin.When vancomycin was combined with etimicin and diuretics , renal toxicity didn′t appear.Conclusion The dose of vancomycin should be adjusted in elder pa-tients.We should monitor serum concentration of vancomycin to adjust its legitimately use.
