IL-33/ST2 signaling pathway′s role in the treatment of diastolic heart failure by using bisoprolol
10.13699/j.cnki.1001-6821.2015.02.010
- VernacularTitle:IL －33／ST2信号通路在比索洛尔治疗舒张性心力衰竭中的作用
- Author:
Bing-Sheng YANG
1
;
Yi-Fei XU
;
Qing-Yun XU
;
Jie CHEN
;
Wei MAO
Author Information
1. 浙江省中医院心内科
- Keywords:
IL-33/ST2;
bisoprolol;
diastolic heart failure;
signaling pathway
- From:
The Chinese Journal of Clinical Pharmacology
2015;(2):113-115
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the IL-33/ST2 signaling pathway′s role in the treatment of diastolic heart failure ( DHF) by using bisoprolol.Methods Twenty four diastolic heart failure rats were randomly divided into control group ( n=12 ) which were given distilled water and the biso-prolol group ( n=12) which were given solution of bisoprolol treatment.The treatment period lasted for 3 months.The data of left ventricular pressure , left ventricular filling time ( LVFT) , left ventricular end-dias-tolic pressure , the maximum rate of isovolumic left ventricular systolic pressure rise were observed in the two groups.The cardiomyocytes ST2 protein and expression of serum TNF -αwere compared.Results The left ventricular systolic pressure and left ventricular mean pressure were significantly lower in bisoprolol group than that in control group ( P <0.05 ) , but there was no statistical difference in left ventricular end -dias-tolic pressure ( P>0.05 ).The maximum rate pressure rise of left ven-tricular systolic content in bisoprolol group was significantly higher than that in the control group ( P<0.05 ) , and the maximum rate of isovolumic left ventricular diastolic pressure decreased significantly than that in con-trol group ( P <0.05 ) , but the LVFT was not statistically different between the two groups ( P<0.05 ).The expression of IL-33 protein in bisoprolol group was significantly lower ( P<0.05 ) , but the ST2 expression and serum TNF -αconcentration between the two groups was not statistically different ( P>0.05 ).Conclusion Bisoprolol may reduce left ventricular blood pressure in diastolic heart failure mice , and im-prove left ventricular compliance , which may be associated with a significant reduction in myocardial cells IL -33 pro-tein expression.
