Pharmacokinetics of dexmedetomidine hydrochloride in anesthesia obese patients
10.13699/j.cnki.1001-6821.2015.02.006
- VernacularTitle:盐酸右美托咪定在全麻肥胖患者体内的药代动力学研究
- Author:
Li REN
1
;
Bo XU
;
Zhi-Tao LI
;
Liu-Xun LI
;
Wei-Feng TU
Author Information
1. 广州军区广州总医院麻醉科
- Keywords:
obese patient;
dexmedetomidine;
pharmacokinetic;
anes-thesia
- From:
The Chinese Journal of Clinical Pharmacology
2015;(2):99-101,115
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the pharmacokinetics of dexmedeto-midine hydrochloride injection in anesthesia Chinese obese patients.Methods Eight obese patients were intravenously injected with dexme-detomidine 1.0 μg· kg-1 after anesthesia.Concentrations of dexmedeto-midine in plasma were determined by HPLC -MS/MS.The pharma-cokinetic parameters were calculated with DAS 2.1.1 software.Results The main pharmacokinetic parameters for the obese patients were as follows:Cmax was (3.33 ±1.20) μg· L-1, t1/2αwas (2.49 ± 0.56 ) min, t1/2βwas ( 163.41 ±116.41 ) min, V1 was ( 162.96 ± 43.26) L, CLz was (4.02 ±1.18) L· min-1, AUC0-t was (123.27 ± 55.96 ) μg · L-1 · min, and MRT0-t was 152.06 min.The results showed that the AUC , Cmax , CLz, and V1 were significantly higher than the patients with normal body mass ( P<0.05 ).Conclusion In obese patients, loading dose should be accompanied with a corresponding re-duction, but doses should be increased at maintaining stage.
