Study on sleep improving mechanism of Paeoniflorin
10.13699/j.cnki.1001-6821.2015.01.017
- VernacularTitle:芍药苷改善睡眠作用机制研究
- Author:
Yue-Feng LI
1
;
Fu-Ju XU
;
Ze-Guo ZHANG
;
Yu-Ping LI
;
Xing-Ke YAN
Author Information
1. 甘肃中医学院 药学院
- Keywords:
SiNiSan Freeze -dry Powder;
Paeoniflorin;
improving sleeping;
mechanism
- From:
The Chinese Journal of Clinical Pharmacology
2015;(1):56-58
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study on sleep improving mechanism of Si Ni San Freeze -dry Powder.Methods Wistar rats were divided into four groups, each group was 10.Which were normal group, Si Ni San powder group, Radix Paeoniae Alba group.Paeoniflorin group.The freeze-dried powder 20 g, water dissolved into 0.5 kg? L-1 solution, administered orally, the normal group were given equal volume of distilled water,1 times a day, continuous 7 d.Blood transitional component were analzed by HPLC method.Results By the analysis of the compound in cerebrospinal fluid, the endogenous substance in cerebrospinal fluid was increased obvi-ously.Increasing peak area of the endogenous substance in cerebrospinal fluid were about 12.5 times the blank′s in cerebrospinal fluid.Conclusion Paeoniflorin in Si Ni San Freeze-dry Powder improves sleep by promo-ting the secretion of 5-serotonin in cerebrospinal fluid.
