Study on plasma concentration assay and bioavailability of freeze -dried albendazole liposomes
10.13699/j.cnki.1001-6821.2015.01.011
- VernacularTitle:阿苯达唑脂质体冻干粉在大鼠体内血药浓度测定及生物利用度研究
- Author:
Hui-Jing GAO
1
;
Chun-Yan CHEN
;
Bei CHEN
;
Jian-Hua WANG
;
Jun ZHAO
Author Information
1. 新疆医科大学 第一附属医院 药学部
- Keywords:
albendazole tablets;
freeze-dried albendazole liposomes;
plasma concentration;
bioavailability
- From:
The Chinese Journal of Clinical Pharmacology
2015;(1):34-37
- CountryChina
- Language:Chinese
-
Abstract:
Objective To establish a HPLC method for the determina-tion of albendazole and its metabolites in rat plasma, and then calculate the relative bioavailability of freeze -dried albendazole liposomes ( L -ABZ).Methods A single oral dose of freeze-dried L-ABZ and al-bendazole tablets( T-ABZ) were given in rats, plasma concentrations at each time point were assayed by HPLC method.The pharmacokinetic pa-rameters were calculated with 3P97 program.Results The pharmacoki-netic parameters of two formulations were as follows: Cmax were(4.32 ± 0.70),(5.27 ±0.60)μg? mL-1; Tmax were (4.71 ±1.17),(5.39 ± 0.94)h;AUC were(63.93 ±13.08),(84.56 ±14.97) μg? h? mL-1, respectively.Compared with the T-ABZ, the relative bioavailability of freeze-dried L-ABZ was 154.17%.Conclusion The pharmacokinet-ics of two formulations accord with the two compartment models and the freeze-dried can improve bioavailability significantly.
