Effect of Guben Kechuan Granules on expression of soluble interleukin-2 receptor of rats with chronic obstructive pulmonary disease
10.13699/j.cnki.1001-6821.2015.01.009
- VernacularTitle:固本咳喘颗粒对慢性阻塞性肺疾病动物可溶性白细胞介素－2受体的影响
- Author:
Wen-Long WANG
1
;
Zi-Kai SUN
;
Li-Hua XU
;
Xuan-Xuan ZHU
Author Information
1. 杭州市中医院 重症医学科
- Keywords:
chronic obstructive pulmonary disease;
soluble interleukin-2 receptor;
Guben Kechuan Granules
- From:
The Chinese Journal of Clinical Pharmacology
2015;(1):28-30
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of Guben Kechuan Gran-ules ( GKG ) on expression level of soluble interleukin -2 receptor (sIL-2R) of rats with chronic obstructive pulmonary disease (COPD). Methods Rat models with COPD made by fumigation and dripping li-popolysaccharide.The rtas were randomly divided into 6 groups:normal group, model group, high, middle, low doses ( 2.28, 1.14, 0.57 g? mL-1 ) GKG groups, and Guben Kechuan Tablets group.From the third day of modeling, medicines were administered to rats by means of intragastric administration for consecutive 28 days.Two days after the fin-ishing of intragastric administration,rats were executed and samples were collected.SIL-2 R expression level in rat was tested by means of ABC-ELISA method.Results SIL-2R expression level in low-dose groups of GKG decreased obviously,with a significant difference compared with model group ( P<0.05).Conclusion GKG can enhance immune func-tion and anti infection ability in the airway of rats with experimental COPD by regulating sIL-2R expression level.
