Oxcarbazepine and carbamazepine in the treatment of primary trigeminal neuralgia:systemic review and Meta-analysis
10.13699/j.cnki.1001-6821.2014.12.017
- VernacularTitle:奥卡西平和卡马西平治疗原发性三叉神经痛的系统评价和荟萃分析
- Author:
Yi-Ming LUO
1
;
Jie-Hui XU
;
Zhan-Miao YI
;
Suo-Di ZHAI
Author Information
1. 北京大学 第三医院 药剂科
- Keywords:
oxcarbazepine;
carbamazepine;
primary trigeminal neuralgia;
Meta-analysis
- From:
The Chinese Journal of Clinical Pharmacology
2014;(12):1130-1134
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the efficacy and safety of oxcarba-zepine and carbamazepine for primary trigeminal neuralgia management.Methods Cochrane library, PubMed, Medline, CBMdisc, CNKI and Wanfang Data were searched to collect the randomized controlled studies that compared the efficacy and safety of oxcarbazepine and carbamazepine in treating primary trigeminal neuralgia.Reference list of each primary study was hand -searched.Two reviewers independently screened the literatures, extracted data, assessed risks of bias and then did cross -checking.RevMan 5.2 software was used for Meta -analysis.Results Eighteen studies ( 1465 participants ) were included.Results of Meta -analysis showed that oxcarbazepine was more effective than carbama-zepine [RR=1.09,95%CI (1.02,1.16), P<0.05].Comparisons of VAS before and after 2 and 4 weeks of treatment were not significantly different between two groups , while comparisons of VAS before and after the 8weeks of treatment favored oxcarbazepine.Oxcarbazepine was asso-ciated with a lower incidence of adverse drug reaction than carbamazepine [RR=0.50,95%CI(0.39,0.63),P<0.001].The influence of repor-ting bias is small.Conclusion Compared with carbamazepine , oxcarba-zepine is not inferior in efficacy but superior in safety in treating primary trigeminal neuralgia.
