In vitro efficacy of cefperazone -sulbactam and meropenem combination against Acinetobacter baumannii
10.13699/j.cnki.1001-6821.2014.12.016
- VernacularTitle:头孢哌酮／舒巴坦联合美罗培南对鲍曼不动杆菌体外抗菌作用研究
- Author:
Wen-Ying XIA
1
;
Ya-Ning MEI
;
Bing GU
;
Gen-Yan LIU
Author Information
1. 南京医科大学 第一附属医院 检验学部
- Keywords:
Acinetobacter baumannii;
cefperazone -sulbactam;
mero-penem;
checkerboard method
- From:
The Chinese Journal of Clinical Pharmacology
2014;(12):1127-1129
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the synergy effect of cefperazone -sulbactam and meropenem combination against 35 meropenem-resistant Acinetobacter baumannii isolated from clinical specimens in vitro.Methods The synergy effect of cefperazone -sulbactam and meropenem combination was evaluated through microdilution checkerboard method a-gainst 35 meropenem resistant A.baumannii were isolated from inpa-tients.The inhibitory concentration against antimicrobials was detected . The synergy effect of combination was assessed by fractional inhibitory concentration index ( FIC).Results The minimal inhibitory concentra-tion ( MIC) of 35 meropenem-resistant Acinetobacter baumannii against cefperazone-sulbactam and meropenem combined were decreased com-pared with single -use ( P<0.01 ).The checkerboard method with the combination of cefperazone -sulbactam and meropenem demonstrated 54.3%(19/35)synergism, 34.3%(12/35)partial synergism, 5.7%(2/35)additive, 5.7%(2/35)indifference, no antagonism in our study.Con-clusion Cefperazone -sulbactam and meropenem combination show syn-ergism or partial synergism against most Acinetobacter baumannii isolates.
