Effect of Paeonol on LC3 expression of liver tissues in mice with liver injury induced by deep partial thickness burns wound
10.13699/j.cnki.1001-6821.2014.12.013
- VernacularTitle:丹皮酚对烫伤诱导小鼠肝损伤肝组织自噬蛋白LC3表达的影响
- Author:
Hong-Bing BO
1
;
Xiao-Bin WANG
;
Xi WANG
;
Xue-Wen GAN
Author Information
1. 解放军第181 医院 整形外科
- Keywords:
Paeonol;
liver injury;
autophagy;
microtubule -associated protein light chain 3
- From:
The Chinese Journal of Clinical Pharmacology
2014;(12):1117-1119
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect of Paeonol on LC 3 expre-ssion of liver tissues in mice with liver injury induced by deep partial thickness burns wound .Methods Mice were randomly divided into con-trol group, model group and Paeonol group .The deep partial thickness burns wound model was made by 90 ℃ water , and the Paeonol group were intragastric administration treatment of Paeonol solution ( 60 mg· kg-1 ).The levels of alanine aminotransferase (ALT) and aspartate aminotransferase ( AST ) in the serum were respectively measured and LC3 expression of liver tissue was observed between 2 h,6 h,12 h,24 h after model established .Results The levels of ALT and AST in the serum of Paeonol group reduced obviously .Compared Paeonol group with model group , the differences were statistically significant ( P <0.05 ) . Meanwhile , Paeonol could induce LC 3 expression of liver tissues .The effects of high -dosage group and medium - dosage group were especially conspicuous .Conclusion Paeonol has better protective effect on liver injury induced with deep Partial thickness burns wound , the mechanism of which is mainly related with inducing LC 3 expression and inhibiting apoptosis of the liver cells .
