Clinical trial of the valsartan/amlodipine compound preparations and the single of two drugs for treatment of moderate and severe hypertension
10.13699/j.cnki.1001-6821.2014.12.001
- VernacularTitle:缬沙坦／氨氯地平复方制剂治疗中重度高血压的临床研究
- Author:
Ji-Feng ZHANG
1
;
Yi-Peng MO
;
Yong-Jun YING
;
Lin XU
;
Pei-Yi XIE
;
Xiong LI
Author Information
1. 浙江省立同德医院 心血管科
- Keywords:
hypertension;
valsartan;
amlodipine;
valsartan/amlodipine compound preparation
- From:
The Chinese Journal of Clinical Pharmacology
2014;(12):1081-1082,1095
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the clinical efficacy and safety of valsartan/amlodipine compound preparations versus amlodipine combined with valsartan for treatment of moderate and severe hypertension.Methods One hundred and twenty subjects with hypertension ( BP≥160/100 mmHg ) were recruited from our hospital in the outpatient ser-vice department.The recruited 120 cases were randomized divided into treatment group and control group with each group of 60 cases.Patients in the treatment group were given valsartan /amlodipine compound prepa-rations (80/5) 85 mg one pil per day for 8 weeks and patients in the control group were given amlodipine 5 mg qd po plus valsartan 80 mg qd po with a treatment period of 8 weeks.The blood pressure and adverse drugs reaction ( ADR) between the two groups were recorded and com-pared.Results The blood pressure was significant decreased in both of two groups after taken the medicine but no statistical difference between the two groups was found ( P>0.05 ).And ADR in the two groups was also no statistical difference ( P >0.05 ).Conclusion The monolithic compound antihypertensive valsartan/amlodipine was reliable and similar to that of monolithic joint valsartan amlodipine.
