Progress on effects of pharmacogenetics of related transporters on improving the individualized thiopurine therapy
10.13699/j.cnki.1001-6821.2014.11.028
- VernacularTitle:影响硫嘌呤类药物个体化应用的相关转运体遗传多态性的研究状况
- Author:
Jing FENG
1
;
Xue-Ding WANG
;
Yong HE
;
Dan LI
;
Jie WU
;
Bing-Zheng SHEN
;
Jin-Chun SONG
Author Information
1. 武汉大学 人民医院 药学部
- Keywords:
thiopurine;
genetic polymorphism;
transporter;
individual variation
- From:
The Chinese Journal of Clinical Pharmacology
2014;(11):1065-1067
- CountryChina
- Language:Chinese
-
Abstract:
Thiopurines, one kind of immunosuppressant, represents an effective and widely prescribed therapy in clinic.There is a growing at-tention paid on the relationship between the individual difference of effi-cacy and side effects of thiopurines and the genetic polymorphisms of rel-evant transporters.Therefore, this review summarizes the correlation of the genetic polymorphisms of relevant transporters and efficacy and ad-verse effects of thiopurines, so as to provide theoretical guidance for indi-vidualized treatment in clinical practice.
