Study status of signaling pathways that regulate ABC transporter activity at the blood-brain-barrier
10.13699/j.cnki.1001-6821.2014.11.025
- VernacularTitle:调控血脑屏障 ABC转运体信号转导通路的研究现状
- Author:
Zhen-Wei XIE
1
;
Yan-Nan ZANG
;
Li-Bo ZHAO
Author Information
1. 北京大学 人民医院 药剂科
- Keywords:
blood brain barrier;
ATP -binding cassette transporter;
signal pathway
- From:
The Chinese Journal of Clinical Pharmacology
2014;(11):1057-1059
- CountryChina
- Language:Chinese
-
Abstract:
ATP-binding cassette ( ABC ) transporters at blood-brain barrier, such as, P-glycoprotein ( P -gp ) , multidrug -resistance -associated protein ( Mrp ) , and breast cancer related protein ( Bcrp ) , can limit central nervous system ( CNS ) uptake of foreign chemicals, drugs and toxicant.ABC transporters are neuroprotective, but they also distinguish poorly between neurotoxicants and therapeutic drugs.So they are major obstacles to CNS pharmacotherapy.Clarifying the mechanisms of these transporters can provide new targets for drugs to get through the blood-brain barrier, which helps to reduce the occurrence of drug re-sistance and improve the effect of treatment.The present review is fo-cused on new findings about ABC transporters and three main signal path-ways, whose are TNF-α/PKCβ/S1PR1 signaling, vascular endothelial growth factor signaling and estrogen signaling.
