Meta-analysis of pharmacokinetic parameters of nifedipine oral formulation
10.13699/j.cnki.1001-6821.2014.11.021
- VernacularTitle:硝苯地平口服制剂药代动力学参数的荟萃分析
- Author:
Xin-Hui ZHANG
1
;
Zhi-Jie CHU
;
Qun LIU
;
Rui-Chen GUO
Author Information
1. 山东大学 药学院
- Keywords:
meta -analysis;
pharmacokinetic parameter;
nifedipine;
multivariate cluster analysis;
ethnic factor
- From:
The Chinese Journal of Clinical Pharmacology
2014;(11):1045-1047,1050
- CountryChina
- Language:Chinese
-
Abstract:
Objective To cluster analysis the population pharmacokinet-ic characteristics of nifedipine.Methods The data of mean pharmacoki-netic parameters and other factors may affecting the pharmacokinetics of drug were collected, normalized, and compared by multivariate cluster a-nalysis procedure using SAS software.Results The pharmacokinetics of Chinese Han population was similar to that of east Asia populations clas-sified as a subgroup, with AUC was (292.53 ±8.01) ng· mL-1 · h, tmax was (0.61 ±0.03) h, Cmax was (140.01 ±11.38) ng· mL-1 and t1/2 was (3.27 ±0.50) h, respectively.Conclusion The meta-analy-sis identified ethnic factor as a statistically significant factor of pharmaco-kinetics, subgroup of people located with Chinese Han population should reduce the dose of formulation.
