Applications of lipidomics in disease biomarkers discovery
10.13699/j.cnki.1001-6821.2014.11.020
- VernacularTitle:脂质组学在疾病生物标记物研究应用现状
- Author:
Lei SHI
1
;
Rui-Chen GUO
;
Chun-Min WEI
Author Information
1. 山东大学 齐鲁医院 临床药理研究所
- Keywords:
lipidomics;
chromatography;
mass spectrometry;
shotgun lipidomics;
biomarker
- From:
The Chinese Journal of Clinical Pharmacology
2014;(11):1041-1044
- CountryChina
- Language:Chinese
-
Abstract:
To clarify the lipid′s effects on diagnosis and treatment of dis-eases and to enhance the ability to predict the disease risks in advance, lipidomics focuses on the structures and functions of lipids and their me-tabolites.Common analytical methods include direct mass spectrometers ( shotgun lipidomics) or chromatography-mass spectrometers and nuclear magnetic resonance.Lipidomics plays an important role in early diagnosis of disease, biomarker discoveries, new drug development and system study.This article reviewed the applications of lipidomics in biomarkers discovery and the technical approaches in lipidome analysis.
