Study on improving constituents of Chinese medicine prescription licorice
10.13699/j.cnki.1001-6821.2014.11.014
- VernacularTitle:甘草改善睡眠作用的药效物质基础研究
- Author:
Xing-Ke YAN
1
;
Ze-Guo ZHANG
;
Fu-Ju XU
;
Chong-Bing MA
;
Yue-Feng LI
Author Information
1. 甘肃中医学院 针推学院
- Keywords:
licorice;
improving sleep;
active constituent
- From:
The Chinese Journal of Clinical Pharmacology
2014;(11):1023-1025
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the pharmacodynamic material basis of licorice andimprove the role of sleep.Methods Thirty Wistar rats were divided into 3 groups, which were normal control group, licorice powder group, glycyrrhetinic acid group.The freeze-dried powder 20 g, water dissolved into 0.5 kg· L-1 solution, administered orally, the normal con-trol group were given equal volume of distilled water.One times a day, continuous 7 d.Blood transitional component were analzed by HPLC method.Results Glycyrrhetinic acid could make the peak area of endog-enous substances in cerebrospinal fluid ( CSF ) higher than the peak area of the blank, the peak area ratio of glycyrrhizin could make the endoge-nous substances in cerebrospinal fluid in the area is about 8.6 times peak area of the blank CSF.That the main chemical components of licorice glycyrrhetinic acid can significantly promote the secretion of endogenous substances in the cerebrospinal fluid, so as to improve the role of sleep.Conclusion By analysis and comparison, which indicates that the active constituent( glycyrrhetinic acid) in licorice are confirmed and could im-prove the sedative function.
