Application value of human epididymis protein 4 in early diagnosis of the ovary cancer
10.13699/j.cnki.1001-6821.2014.11.006
- VernacularTitle:人附睾蛋白4在卵巢恶性肿瘤早期诊断中的作用
- Author:
Li-E ZHENG
1
;
Jun-Ying QU
;
Sang LI
;
Yu-Hong SU
Author Information
1. 福建医科大学 附属第一医院 妇科
- Keywords:
human epididymis protein 4;
carbohydrate antigen -125;
differential diagnosis of the ovary tumor;
pathologic typing;
electrochemical luminescence method;
immunohistochemistry
- From:
The Chinese Journal of Clinical Pharmacology
2014;(11):996-999
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine the value of human epididymis pro-tein 4 ( HE4) in the diagnosis and prognosis of ovarian cancer.Methods We use the clinical case -control method, in which the level of HE4 and carbohydrate antigen -125 ( CA125 ) before operation in clinical case and normal women were detected.An immunohistochemistry meth-od was used to measure the expression of HE4 in different tissues.Statis-tical analysis was performed to determine the relationship between the level of HE4, the pathologic type of ovarian cancer, and the stage of the ovarian tumor.Results If the level of HE4 in the serum was 56.37 pmol· L-1 , the sensitivity of HE4 in diagnosing the malignant ovary tumor was 80%and the specificity was 96%.The level of HE4 and the pathological differentiation are negatively related and positively related to the clinical staging .HE4 in the malignant tumor group and borderline tumor group was higher than in other 3 groups, which contained bening ovary tumors, non-neoplastic lesions of ovary and other malignant gyne-cologic tumors.The HE4 level in the serum and HE4 in the tissue were relatively linked.Conclusion HE4 sensitivity and specificity in diagno-sing the ovary malignant tumor is higher than the sensitivity of CA125.The combined detection of HE4 and C125 is more effective.The level of HE4 in serum and HE4 in tissue was respectively closely related to the pathological type and clinical sequelae of the ovary malignant tumor.
