Eficacy and safety of the sublingual immunotherapy with standardized dermatophagoides farinae drops in children with allergic rhinitis
10.13699/j.cnki.1001-6821.2014.11.004
- VernacularTitle:粉尘螨滴剂治疗儿童变应性鼻炎的疗效及安全性
- Author:
Yong LI
1
;
Gui-Yin RUAN
;
Hong-Juan CHU
;
Bo JIANG
;
Bao-Hong TAO
Author Information
1. 浙江台州学院 附属市立医院 耳鼻咽喉科
- Keywords:
rhinitis;
allergic;
immunotherapy;
dermatophagoides farin;
curative effect
- From:
The Chinese Journal of Clinical Pharmacology
2014;(11):991-993
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the efficacy and safety of sublingual immunotherapy with dermatophagoides farinae standardized extrace for the treatment in children with allergic rhinitis for 2 years.Methods Two hundred and forty children with allergic rhinitis to dermatophagoides ptero-nyssinus( Der P) were randomly allocated to receive either specific immu-notherapy(n=120)or medical treatment(n=120).Symptom and medica-tion scores were assessed to evaluate the clinical efficacy and safety in the baseline and after two year treatment.Results Immunotherapy reduced the symptom [the scores reduced from (10.76 ±1.08) to (3.46 ±0.85)] and medication score [the scores reduced from (1.28 ±0.68) to (0.28 ± 0.43)] in children with allergic rhinitis significantly ( P <0.05), and compared with the control group [ ( 9.76 ±1.14 ) and ( 1.09 ±0.35 ) ] , there was a statistical difference (P<0.05).Eleven local adverse reactions including allergic rash and nasopharyngeal itching occurred observation group, and ten cases of nasal bleeding, fatigue and drowsiness were found in control group, while no fatal systemic reaction occurred in both groups.Conclusion Dermatophagoides farinae standardized extrace for the treat-ment of allergic rhintis is efficacious to treat children sensitive to Der P, al-lergen individualization of dosage is recommended to improve tolerance and security.
