Sorafenib on clinical application and drug interaction
10.13699/j.cnki.1001-6821.2014.10.027
- VernacularTitle:索拉非尼的临床应用和药物相互作用
- Author:
Jian-Long ZHAO
1
;
Hui ZHAN
;
Yue YANG
;
Wen-Zhe LI
;
Zhong-Hui WANG
;
Xiang-Jun QIU
Author Information
1. 河南科技大学 医学院
- Keywords:
sorafenib;
clinical application;
drug interaction;
therapeu-tic drug monitoring;
tyrosinekinase inhibitor
- From:
The Chinese Journal of Clinical Pharmacology
2014;(10):958-961
- CountryChina
- Language:Chinese
-
Abstract:
Sorafenib is a multi -targeted tyrosinekinase inhibitor , and mainly used for the treatment of advanced renal cell carcinoma and hepa -tocellular carcinoma.The pharmacokinetic changes of sorafenib caused by drug -drug interactions may affect its clinical efficacy and safety, so individualized treatment drug monitoring could control the occurrence of potential drug interactions.In this paper, the clinical applications and drug -drug interaction of sorafenib was reviewed .
