Study on the stability of cefazolin sodium pentahydrate
10.13699/j.cnki.1001-6821.2014.10.021
- VernacularTitle:五水头孢唑林钠稳定性研究
- Author:
Yan JIANG
1
;
Yang CHU
;
Yi-Fan LUO
;
Ming-Yan JIANG
Author Information
1. 中国医科大学 附属第一医院
- Keywords:
cefazolin sodium pentahydrate;
cefazolin sodium;
stability
- From:
The Chinese Journal of Clinical Pharmacology
2014;(10):939-941,973
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the difference of stability be-tween cefazolin sodium pentahydrate and amorphous cefazolin sodium. Methods Cefazolin sodium pentahydrate and amorphous cefazolin sodium from two manufacturers were processed rubber plug inverted test and vibration test, and then dissolved in the sterile water for injec-tion and 0.9% sodium chloride injection.The dissolving process was observed by an optical microscopy.Results In rubber plug inverted test and vibration test, cefazolin sodium pentahydrate almost was dis-solved while amorphous cefazolin sodium had different degrees of un-dissolved drugs by microscope observation.Conclusion The stability of cefazolin sodium pentahydrate is superior to that of amorphous ce-fazolin sodium.
