Study on effects of Sini San on the sleeping phase in rats
10.13699/j.cnki.1001-6821.2014.10.020
- VernacularTitle:四逆散对大鼠睡眠时相影响的实验研究
- Author:
Yue-Feng LI
1
;
Fu-Ju XU
;
Ze-Guo ZHANG
;
Xing-Ke YAN
Author Information
1. 甘肃中医学院 药学院
- Keywords:
freeze - dry powder of Sini San;
sleeping phase;
electroencephalogram
- From:
The Chinese Journal of Clinical Pharmacology
2014;(10):936-938
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study on the effects of freeze -dry powder of Sini San on sleep in rats.Methods Rats were randomly divided into two groups (freeze -dry powder of Sini San and blank groups )of 15 each day to ensure the alternating light and dark 12 h.The postoperative recovery after two days, rats were continuously administered orally by freeze -dry powder of Sini San 4.95 g? kg-1 for 7 days.Blank group was given dis-tilled water by intragastric way.The other disposal methods were the same with administration group.The efficacy of Sini San on sleeping phase of normal and insomnious rats are carried out by electroencephalo -gram (EEG).Results The total sleeping time (TST) of rats were sig-nificantly prolonged induced by pentobarbital sodium , especially slow -wave sleep 2 (SWS2) and rapid -eye -movement sleep (REMS) were prolonged after the rats were orally administrated of Sini San freeze -dry powder for seven days.The result indicated that Sini San can significant effect on improving sleep.Conclusion There was the function of Sini San in the treatment for insomnia.
