Clinical study of docetaxel plus cisplatin regimen combined with parenteral enteral nutrition on the treatment of gastric cancer
10.13699/j.cnki.1001-6821.2014.10.009
- VernacularTitle:多西他赛和顺铂新辅助化疗联合肠内肠外营养治疗胃癌幽门梗阻临床研究
- Author:
Jin-Xi HUANG
1
;
Tie-Jun YANG
;
Cheng-Hu WANG
;
Wei-Wei YUAN
;
Xiao-Bing CHEN
;
Bei-Bei CHEN
;
Yi ZHOU
Author Information
1. 郑州大学 附属肿瘤医院 普外科
- Keywords:
gastric cancer;
pyloric obstruction;
complication;
neoadju-vant chemotherapy
- From:
The Chinese Journal of Clinical Pharmacology
2014;(10):901-903
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the clinical efficacy and safety of docetaxel plus cisplatin ( DP) chemotherapy regimen combined with parenteral enteral nutrition in the treatment of gastric cancer .Methods Seventy -three gastric cancer patients with pyloric obstruction were recruited in this study.Of the included 73 patients, 42 subjects (control group) received surgery immediately on diagnosis and other 31 subjects (treatment group) received neoadjuvant chemotherapy of DP regimen combined with parenteral enteral nutrition before the surgery .The clinical efficacy and complications in the two groups were compared after the surgery.Results The radical resection rates were 87.1%(27 /31) in the treatment group and 71.4% (30 /42 ) in the control group ( P <0.05).The Complication incidences were much lower in treatment group compared with those of control group (P all <0.05), such as abdominal infections, lung infections and stomach paralysis. Conclusion DP chemotherapy regimen combined with parenteral enteral nutrition can enhance the radical resection rate and decrease the general complications in the treatment of gastric cancer patients with pyloric obstruction.
