Clinical effects of tripterygium glycosides in treatment of children with henoch -schonlein prupura nephritis and its influence on immunologic function
10.13699/j.cnki.1001-6821.2014.10.007
- VernacularTitle:雷公藤多苷治疗小儿紫癜性肾炎疗效及对患儿免疫功能的影响
- Author:
Ping LI
1
;
Chun-Rong HUANGFU
;
Chun-Hui TANG
Author Information
1. 云南省第一人民医院 儿科
- Keywords:
tripterygium wilfordii polyglycosidium;
children;
henoch -schonlein prupura nephritis
- From:
The Chinese Journal of Clinical Pharmacology
2014;(10):895-897
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the clinical effects of tripterygium wilfordii polyglycosidiums(TWP) in treatment of children with henoch -schonlein prupura nephritis (HSPN) and effects on theeir imunologic func-tion.Methods Sixty -seven children with HSPN and 26 healthy children were recruited and HSPN subjects were randomly divided into control group (n =35) and treatment group (n =32).Children in control group were given rest, antianaphylaxis and anticoagulation regular treatment . And Children in treatment group were given TWP 1.5 mg? kg-1 ? d-1 , divided into three times, as well as the regular treatment.After 12 -week treatment, the total remission, side effect and the serum IL -10, IL -8 and TNF -αwere recorded and compared between the HSPN group and healthy group.Results The total remission were 90.6% and 50.3% in the treatment group and control group respectively , which showed that treatment group was much higher (P <0.05).The serum immune function (IL -8,IL -10 and TNF -α) were significantly improved in both of the two group(P <0.05), which indicated a much higher improvement was found in the treatment group (P <0.05).But the IL -8,IL -10 and TNF -αwas statistically different from the healthy children (P <0.05). Three case of elevated transaminase and 2 cases of neutropenia were found during the treatment in the treatment group . Conclusion TWP had percise efficacy and slight side effect on children with HSPN and the immune function could be improved by TWP.
