Clinical observation of rat nerve growth factor combined with αlipoic acid for treatment of diabetic peripheral neuropathy
10.13699/j.cnki.1001-6821.2014.10.006
- VernacularTitle:鼠神经生长因子联合α-硫辛酸治疗糖尿病周围神经病变的临床观察
- Author:
Chang-Rong GUAN
1
;
Ying-Biao ZHU
;
Li DING
;
Ri-Qiu CHEN
Author Information
1. 丽水市人民医院 内分泌科
- Keywords:
rat nerve growth factor;
α-lipoic acid;
diabetic peripheral neuropathy;
high sensitivity C -reactive protein
- From:
The Chinese Journal of Clinical Pharmacology
2014;(10):892-894,900
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the efficacy and safety of the rat nerve growth factor combined with αlipoic acid in the treatment of diabetic periph-eral neuropathy (DPN).Methods Eighty -eight patients with DPN were randomly divided into two groups and they were given diabetes diet and insu -lin or oral hypoglycemic agents to control blood sugar.The control group (n =43) was given αlipoic acid 0.6 g,qd; the trial group (n =45) were given rat nerve growth factor injection 20 μg based on the control group,im, qd.Twenty -one days as a treatment cycle.Before and after treatment, the total symptom score(TSS) ,the nerve conduction velocity(NCV),microalbu-minuria and high sensitivity C -reactive protein were tested and recorded respectively before and after treatment in 2 groups.Results The NCV of the trial group was higher than those of the control group (P <0.01); after treatment,TSS was significantly lower in the trial group than in the control group (P <0.01); the microalbuminuria and high sensitivity C -reactive protein of the trial group descended more apparently than those of the control group (P <0.05).The total effective rate of the trial group was higher than that of the control group (P <0.05).Conclusion Rat nerve growth factor combined with αlipoic acid treatment is safe and effective for the treatment of diabetic peripheral neuropathy.
