Excretion of ligustrazine hydrochloride in Salviae Miltiorrhiza and Ligustrazine Hydrochloride Injection in rats
10.13699/j.cnki.1001-6821.2014.09.016
- VernacularTitle:丹参川芎嗪注射液中盐酸川芎嗪的大鼠排泄特征研究
- Author:
Xiao-Juan LIU
1
;
Ling WANG
;
Shuang LU
Author Information
1. 四川大学 华西药学院
- Keywords:
Salviae Miltiorrhiza and Ligustrazine Hydrochloride Injec-tion;
ligustrazine hydrochloride;
excretion;
urine;
bile
- From:
The Chinese Journal of Clinical Pharmacology
2014;(9):803-806
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the excretion characteristics of ligus-trazine hydrochloride in Salviae Miltiorrhiza and Ligustrazine Hydrochlo-ride Injection in rats.Methods Rats were injected 20 , 40 and 80 mg· kg-1 Salvia Miltiorrhiza and Ligustrazine Hydrochloride Injection by caudal vein, respectively.The urine and bile were collected at 0 -4, 4-8, 8-12, 12-24 h and 0-2, 2-4, 4-6, 6-12, 12-24 h, respectively.The concentrations of ligustrazine hydrochloride in urine and bile were measured by HPLC.Results After intravenous injection different doses of Salviae Miltiorrhiza and Ligustrazine Hydrochloride Injection in rats, few ligustrazine hydrochloride was excreted in urine and bile as prototype.Conclusion The results indicate that prototype was not the main elimination form of ligustrazine hydrochloride in rats.
