Influence of rosuvastatin on inflammatory factors in rats with focal cerebral ischemia-reperfusion
10.13699/j.cnki.1001-6821.2014.09.011
- VernacularTitle:瑞舒伐他汀对大鼠脑缺血再灌注后炎性因子的影响研究
- Author:
Guo-Qian LI
1
;
Shu-Zeng CHEN
;
Jie-Hua WANG
;
Xiu-Xiu XU
;
Wen-Dong LIN
;
Yong-Hua XIE
Author Information
1. 福建医科大学 附属泉州第一医院 神经内科
- Keywords:
rosuvastatin;
cerebral ischemia -reperfusion;
interleukin -10;
interleukin-18
- From:
The Chinese Journal of Clinical Pharmacology
2014;(9):788-790
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe effects of rosuvastatin on the expres-sion of interleukin -10 ( IL-10 ) and interleukin -18 ( IL -18 ) in rats with focal cerebral ischemia -reperfusion.Methods Rats were randomly assigned into three groups:sham operation group ( sham group ) ,focal cere-bral ischemia-reperfusion group ( model group ) and rosuvastatin precondi-tioning group ( test group ) .Before making a model , the rats in the test group were lavaged with rosuvastatin 5 mg· kg-1 · d-1 ,once a day for 10 consecutive days.The middle cerebral artery occlusion reperfusion model was made by the suture method (ischemia for 1 hour, and reperfusion for 12 hours ).The level of IL-10 and IL-18 expression were measured by ELISA and PCR.Results Compared with model group , the expression of IL-10 significantly was increased while the expression of IL -18 was significantly decreased in test group (P<0.05).Conclusion Rosuvastatin can regulate IL-10 and IL-18 levels in rats with focal cerebral ischemia -reperfusion, which was new treatment targets for cerebral ischemia.
